Heparinases I/II/III

Heparinases (or heparin lyases) are a group of enzymes that catalyze the cut of heparin (and / or heparan sulfate) with the release of oligosaccharides (mainly disaccharides) containing unsaturated uronic acid. Heparinases create a double bond on the non-reducing end of the uronic acid that absorbs at 232 nm so the reaction can be used for the detection of oligosaccharide and disaccharide products which are directly correlated with the activity of heparinases.

Applications

Heparinases, thanks to their mechanism of action, are widely used in the field of pharmacology for the production of Low Molecular Weight Heparins (LMWH) wich are are currently the treatment of choice in the prevention and treatment of numerous thromboembolic diseases thanks to their greater practicality of use compared to the High Molecular Weight Heparins (HMWH) wich are Heparinases substrates.

There are specific diagnostic kits that require the use of heparinases to neutralize heparin from blood and plasma samples before they are analyzed.

Formulation and pack size

Heparinase I, Heparinase II and Heparinase III from Flavobacterium heparinum (ATCC 13125) are produced recombinant and are available in liquid formulations with glycerol; each enzimatic solution is 0.22 µm sterile filtered and dispensed in sterile vials; find below the different pack size available for each enzyme.

HEPARINASE I

Code: Hep I-10: 10 U/vial, 1 vial/cf

Code: Hep I-2: 2 U/vial, 1 vial/cf

Code: Hep I-20: 20 U/vial, 1 vial/cf

Code: Hep I-5: 5 U/vial, 1 vial/cf

Code: Hep I-50: 50 U/vial, 1 vial/cf

HEPARINASE II

Code: Hep II-0,1: 0,1 U/vial, 1 vial/cf

Code: Hep II-0,25: 0,25 U/vial, 1 vial/cf

Code: Hep II-0,5: 0,5 U/vial, 1 vial/cf

Code: Hep II-1: 1 U/vial, 1 vial/cf

Code: Hep II-10: 10 U/vial, 1 vial/cf

Code: Hep II-2: 2 U/vial, 1 vial/cf

Code: Hep II-5: 5 U/vial, 1 vial/cf

HEPARINASE III

Code: Hep III-0,5: 0,5 U/vial, 1 vial/cf

Code: Hep III-1: 1 U/vial, 1 vial/cf

Code: Hep III-10: 10 U/vial, 1 vial/cf

Code: Hep III-2: 2 U/vial, 1 vial/cf

Code: Hep III-5: 5 U/vial, 1 vial/cf